Abstract: This study was conducted to evaluate the effect of high concentrate diets on ruminal and cecal fermentation and biogenic amines production and absorption in the gastrointestinal tract of goats. Six goats fitted with permanent rumen fistula were randomly divided into low concentrate group and high concentrate groups for an experiment that lasted 24 days. The results showed that, compared with the low concentrate group, high concentrate diets increased the concentrations of total volatile fatty acid, acetate, propionate, butyrate, total branched chain fatty acid, tyramine, putrescine, histamine, methylamine and tryptamine (P<0.05). Ruminal pH and the ratio of acetate to propionate decreased (P<0.05). A high concentrate diet also improved the levels of acetate, propionate, total volatile fatty acid and the five biogenic amines in cecal digesta (P<0.05). Compared with the control group, the concentrations of biogenic amines contents were higher in the high concentrate group in rumen and cecal vein blood (P<0.05). Correlation analysis revealed that the biogenic amines contents of tyramine, putrescine, methylamine and tryptamine in rumen fluid and rumen vein blood were significantly positively correlated (P<0.05). In addition, significant correlations of the five amines contents were observed between cecal digesta and cecal vein blood (P<0.05). These results show that high concentrate diets significantly affect ruminal and cecal fermentation, indicating that high concentrate feeding might increase ruminal and cecal epithelial permeability and thus stimulate the absorption of biogenic amines from rumen and cecum.