Abstract: Alopecurus myosuroides is a major weed in Europe. Originally, it was only found in Taiwan but now it is a worsening problem in mainland China, including Shandong, Hebei, and Shanxi. However, there is no information about control using chemical herbicides in China. Field experiments were conducted to determine the effectiveness of control and the response of winter wheat to different rates of eight herbicides spraying at different timings during the 2013-2014 growing seasons in Jinan, Shandong province. The results showed that pyroxsulam provided best control on A. myosuroides with a 97.1%-100.0% fresh weight (FW) reduction after application irrespective of application time. Mesosulfuron-methyl also gave good control with 80.1%-98.6% FW reduction. Pinoxaden produced good control (99.3%-99.9% FW reduction) if applied before winter, but was less effective applied during winter (74.1%-88.9% FW reduction) and spring (46.2%-75.8% FW reduction). Clodinafop-propargyl and fenoxaprop-p-ethyl had good effect with 81.1%-96.8% FW reduction applied before winter and in early spring but had reduced effectiveness applied during winter (41.4%-76.0% FW reduction). Isoproturon, traloxydim and flucarbazone-Na failed to control A. myosuroides at any applying timing.