Abstract: Soil-borne diseases have been a major main factor restricting the development of agriculture and animal husbandry in China. Recently, greater attention has been paid to food safety and environment protection, which requires a greater focus on sustainable development of agriculture and animal husbandry. Biological control of plant disease, is not only low-cost and efficient but also safe and environmentally friendly, and has become a research priority in plant disease control, both domestically within China and overseas. This review summarizes the research progress in biological control of soil-borne disease through optimization of cultural practices, biocontrol of antagonistic organisms and induced systemic resistance. The problems of biological control and the future prospects for successful use of biological control are also indicated.