Abstract: A field experiment was conducted to investigate the influence of different fertilizer formulae on the growth of safflower (Carthamus tinctorius) on a secondary salinization soil in a drought irrigation area. Application rates of N, P, and K was designed with a “3414” strategy, a method generally used for fertilization formulae experiments. Application rates of N, P, and K had significant effects on plant height, ramose tallness, numbers of flowers, yield of flowers, and grain yield of Safflower. N₂P₂K₂ (namely N∶P∶K=180∶90∶120) treatment gave the highest yield of flowers and grain production. A step by step regression curve was done to determine the relationship of corolla production and grain yield of Safflower with application rates of N, P and K. It showed that a fertilizer application rate of N 150.59 kg/ha, P₂O₅ 93.09 kg/ha and K₂O 98.75 kg/ha was good for corolla production, and the highest theoretical yield was 667.98 kg/ha. For grain yield, the best fertilizer application rate was N 169.50 kg/ha, P₂O₅ 94.60 kg/ha and K₂O 102.75 kg/ha, giving the highest theoretical grain yield of 2 644.47 kg/ha on secondary salinization soil in a drought irrigation area.