Abstract: In the Shiyang River basin, the environmental deterioration caused by excessive nitrogen (N) and irrigation application in agricultural ecosystems has received much attention in recent years. A combination of careful irrigation and N management is needed to improve grain yield and water use efficiency (WUE) in the arid oasis agricultural area of Northwest China. A field experiment was conducted to investigate the effects of different irrigation and N application rates on water consumption, grain yield and water use efficiency on no-tillage farmland with standing stubble in the oasis region of the Shiyang River basin, Gansu province. The experiment followed a completely randomized split-plot design, taking flood irrigation (conventional irrigation 327 mm), 20%water-saving irrigation (261 mm), 40%water-saving irrigation (196 mm) and N fertilizer application rates (0, 140, 221, 300 kg N/hm²) as the main-plot and split-plot, respectively.Under the experimental conditions, irrigation supply increased the soil water content in 80-120 cm depth measured 24 h before irrigation and in 0-80 cm depth measured 24 h after irrigation. Nitrogen application has no significant effects on the soil water content in 0-120 cm depth. Soil water storage and water consumption rate were increased with amount of irrigation. The soil water storage in the treatments without nitrogen application was significantly higher than that with nitrogen application. Nitrogen application did not significantly affect water consumption rate. When the rate of N application was 221 kg/N hm², the grain yield (6 365 kg/hm²) and WUE (14.51 kg/hm²·mm) were reached the maximum among other N treatments across irrigation regimes. Spring wheat (Triticum aestivum) grain yield were increased with the amount of irrigation. The increases of grain yield in traditional irrigation were 8.2% and 32.2% when compared with 20% water-saving irrigation and 40% water-saving irrigation. The differences of WUE between different irrigations were not significant.