Effect of alfalfa flavonoids on growth and reproduction performance of female rats

Abstract

Abstract: The impact of different doses of alfalfa flavonoids on growth, reproduction and endocrine systems in female rats was studied using three doses of alfalfa flavonoids (120, 400, and 1 200 mg/kg) and two control groups (diethylstilbestrol 0.5 mg/kg and blank control group). Estradiol (E2), prolactin (PRL), progesterone (P), and growth hormone (GH) were determined by chemiluminescence. Related data of rat reproduction were uterine wet weight/coefficient, ovarian wet weight/coefficient, feed intake, daily body gain, litter size and newborn litter weight of rats. The low doses of alfalfa flavonoids increased the E2 level and uterine wet weight/coefficient (P<0.05) but significantly (P<0.05) reduced the ovarian wet weight/coefficient in mature female rats. GH levels were not significantly different in immature female rats but the middle and high dose groups had markedly reduced uterine wet weight/coefficients (P<0.05). However, feed intake was not significantly different although litter size and newborn litter weight had an increased trend in mature female rats. Litter size of middle and high dose groups increased 0.4% and 2.2% more than the blank control group (P>0.05). Newborn litter weight of middle and high dose groups increased 5.14% and 0.10% more than the blank control group (P>0.05). Therefore, different doses of alfalfa flavonoids influenced hormone secretions and the development of the reproductive organs before mating. Alfalfa flavonoids resulted in a significantly improved reproduction performance.

CLC Number:

WANG Wei, MA Deng-tan, ZHAI Xin-ying, WANG Cheng-zhang, TIAN Miao-miao, YAN Xue-bing. Effect of alfalfa flavonoids on growth and reproduction performance of female rats[J]. Acta Prataculturae Sinica, 2013, 22(2): 100-108.

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